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KMID : 0614619930250020345
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Korean Journal of Gastroenterology
1993 Volume.25 No. 2 p.345 ~ p.351
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Assessment of Fibrosis in Chronic Hepatitis with Serum Collagen Type IV-7S
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김안나
김성용/임선희/임용성/이계희/손 인/박성훈/최신은
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Abstract
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The degree of fibrosis is a major prognostic factor in chronic liver disease. Although liver biopsy is essential to assess the degree of fibrosis, a more simple diagnostic method would be helpful for its invasive nature. Type IV collagen is one
of
major
constituents of basement membrane and serum collagen IV-7S level reflects the degree of fibrosis.
To evaluate the usefulness of serum collagen IV-7S in assessing the state of hepatic fibrosis. We compared the level of serum collagen IV-7S in various liver diseases and normal volunteers. The normal value of the serum collagen IV-7S was
3.6±1.2
ng/ml There was no statistically significant difference in serum collagen IV-7S levels among the group of acute hepatitis, fatty liver, chronic persistent hepatitis and the normal controls. And there was no significant difference between the
group
of
chronic active hepatitis and liver cirrhosis, either, But the level of serum collagen IV-7S of the group of chronic active hepatitis and liver cirrhosis was significantly higher than that of the group of acute viral hepatitis, fatty liver and
chronic
persistent hepatitis.
These results suggest that the measurement of serum collagen IV-7S is a valuable aid for evaluating the state of fibrosis in chronic liver disease.
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KEYWORD
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